Illumina Begins Shipping New Mouse Genome Oligo Set
Tuesday December 14, 6:30 pm ET
Publicly Available Probe Sequences Developed in Collaboration with Leading Genomics Research Centers
SAN DIEGO--(BUSINESS WIRE)--Dec. 14, 2004--Illumina, Inc. (NASDAQ:ILMN - News) announced today that it has synthesized and begun shipping a new Oligator® mouse genome oligo set for spotted gene expression arrays. Developed in collaboration with leading researchers, the new MEEBO (mouse exonic-evidence-based oligonucleotide) Set contains 38,467 70-mer probe sequences and is designed for the study of mouse transcription and alternative splicing patterns, allowing interrogation of nearly 25,000 mouse genes.
Illumina developed the new mouse oligo set in collaboration with five research institutions: University of California, San Francisco (UCSF), the Stowers Institute for Medical Research, Stanford University, Rockefeller University, and the University of Basel, Switzerland. These institutions commit extensive resources to the study of the mouse as a model organism for understanding the genetic basis of human disease.
An exon-based probe design approach was used for the MEEBO Set, allowing a researcher to interrogate alternatively spliced transcripts. In addition to the exon-centric probes, the set contains an extensive assortment of controls that facilitate accurate evaluation of expression results. Probes in the MEEBO Set are amino-modified on the 5' end, supplied at a final yield of 200 pmol per probe sequence, and delivered in 101 384-well microarray print plates. Set specifications, including a complete list of probe information and sequences, are available at: illumina.com .
According to Tom Rosso, Illumina's oligonucleotide business manager, "Our collaborative approach to designing this set ensures that probe content will meet the needs of a broad, international group of mouse researchers. Importantly, we fully disclose and make freely available all probe sequences, consistent with our open design policy. The MEEBO Set design is generating significant interest in the mouse research community and we're pleased to report strong demand for the new set."
Illumina (www.illumina.com) is developing next-generation tools that permit large-scale analysis of genetic variation and function. The Company's proprietary BeadArray(TM) technology -- now used in leading genome centers around the world -- provides the throughput, cost effectiveness and flexibility to enable researchers in the life sciences and pharmaceutical industries to perform the billions of tests necessary to extract medically valuable information from advances in genomics and proteomics. This information will help pave the way to personalized medicine |
