>> Didn't Debi Nayak and Marcell Baluda teach virology? SARS CoV is a coronavirus (SS-RNA plus strand), which is Mike Lai's specialty. Didn't he teach an RNA virology grad course while you were there? <<
Yes, Debi Nayak and Marcel Baluda taught Virology. But you're a fake, trying to piece together something that sounds intelligent from PubMed. You therefore don't know that Baluda and Nayak taught Virology at UCLA, and were both faculty members in the department where I did my grad work, Medical Microbiology and Immunology, School of Medicine.
And, yes, Lai is the coronavirus expert. We published this work together when I was a grad student at USC (second postdoc)......
Virology. 1983 Dec;131(2):296-307.
Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus.
Fleming JO, Stohlman SA, Harmon RC, Lai MM, Frelinger JA, Weiner LP.
Monoclonal antibodies were produced to JHMV-DL, a neurotropic member of the mouse hepatitis virus (MHV) or murine coronavirus group. Of 23 antibodies isolated, 10 were specific for the major envelope glycoprotein, gp180/90, 10 for the nucleocapsid protein, pp60, and 3 for the minor envelope glycoprotein, gp25. Eleven different MHV isolates were used in antibody binding assays to study antigenic relationships among the viruses. Each MHV isolate tested had a unique pattern of antibody binding, indicating that each is a distinct strain. Conservation of JHMV-DL antigenic determinants varied among the three proteins, with pp60 showing intermediate conservation, gp180/90 little conservation, and gp25 marked conservation in the different MHV strains. Monoclonal antibodies to pp60 proved most useful in delineating antigenic relationships among MHV strains. These antigenic groups correlated with pathogenic types, indicating that pp60 may be one of the gene products which mediates the distinct disease patterns manifested by different murine coronaviruses. |
