United States Patent Application 20040213816
Kind Code A1
Weiner, David M. ; et al. October 28, 2004
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Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Abstract
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
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Inventors: Weiner, David M.; (San Diego, CA) ; Davis, Robert E.; (San Diego, CA) ; Brann, Mark R.; (Del Mar, CA)
Correspondence Name and Address: KNOBBE MARTENS OLSON & BEAR LLP
2040 MAIN STREET
FOURTEENTH FLOOR
IRVINE
CA
92614
US
Serial No.: 759561
Series Code: 10
Filed: January 15, 2004
U.S. Current Class: 424/239.1; 514/221; 514/317; 514/567
U.S. Class at Publication: 424/239.1; 514/317; 514/221; 514/567
Intern'l Class: A61K 031/5513; A61K 039/08; A61K 031/445; A61K 031/198
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Claims
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What is claimed is:
1. A composition comprising a compound of Formula (I): 10and a pharmaceutically acceptable carrier.
(snip, 86 claims total)
two months old, I'm just posting it in the event that it has useful search terms for others, and hoping that the discussion of intellectual property which started elsewhere can expand in this thread. |
