Thanks Peter!
Do you have access to the papers?
Mda7 will be getting a bunch of attention in January..
[edit: thanks to YMB]
one of the authors(Fisher) in the last citation discovered the Mda7 gene at Columbia University and licensed it to INGN..
Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S. Related Articles,Links
Intratumoral Injection of INGN 241, a Nonreplicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (mda-7/IL24): Biologic Outcome in Advanced Cancer Patients.
Mol Ther. 2005 Jan;11(1):160-72.
PMID: 15585417 [PubMed - in process]
2: Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, Mhashilkar A, Parker K, Vukelja S, Richards D, Hood J, Coffee K, Nemunaitis J. Related Articles,Links
Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.
Mol Ther. 2005 Jan;11(1):149-59.
PMID: 15585416 [PubMed - in process]
3: Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Gupta P, Nemunaitis J, Cunningham C, Yacoub A, Dent P, Fisher PB. Related Articles,Links
mda-7/IL-24: Exploiting Cancer's Achilles' Heel.
Mol Ther. 2005 Jan;11(1):4-18. |
