2005 - NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference.
1: Brain Res Bull. 2005 Jan 30;64(6):493-503. Related Articles, Links
NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference.
Ribeiro Do Couto B, Aguilar MA, Manzanedo C, Rodriguez-Arias M, Minarro J.
Departamento de Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Avda. Blasco Ibanez, 21 46010 Valencia, Spain.
The effects of dopaminergic and glutamatergic antagonists on the drug-induced reinstatement of a previously extinguished morphine conditioned place preference (CPP) in mice were evaluated. Following extinction of a place preference induced by morphine (40mg/kg), a non-contingent injection of the dopaminergic antagonists SCH 23390 (0.125, 0.5mg/kg), raclopride (0.3, 1.2mg/kg), haloperidol (0.1, 0.2mg/kg) and the dopamine (DA) release inhibitor CGS 10746B (1, 10mg/kg) or glutamatergic NMDA antagonists memantine (10, 20, 40mg/kg) and MK-801 (0.1, 0.2, 0.3mg/kg) alone or with 10mg/kg morphine was given. Neither the dopaminergic nor the glutamatergic antagonists alone reinstated the place preference. Dopamine antagonists failed to block the morphine-induced reinstatement of place preference while memantine and MK-801 blocked it with intermediate and high doses. These results suggest that drug-induced reinstatement of place preference may be largely independent of dopamine and more closely related to glutamatergic neurotransmission.
PMID: 15639545 [PubMed - in process]
ncbi.nlm.nih.gov |
