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Biotech / Medical : Rigel Pharmaceuticals, Inc. (RIGL)
RIGL 36.18-4.5%3:59 PM EST

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From: mopgcw1/23/2005 10:10:44 AM
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From BioCentury: Rigel (RIGL) fell $1.71 to $20.06 last week despite partnering
with Pfizer (PFE) to develop RIGL’s preclinical Syk kinase
inhibitors for allergic asthma and other respiratory diseases (see
B4).
Moreover, RIGL retained rights to its lead Syk kinase inhibitor,
R112, which is in Phase II trials for allergic rhinitis. PFE does
have a “limited option” to license the compound after RIGL
completes additional Phase II trials, but EVP and COO Raul
Rodriguez noted that the pharma company’s option “is soft — we
don’t have to give it to them.”
Rodriguez said RIGL wants to run the additional Phase IIs on
its own and expects to partner the compound in the next 12
months. “We’re starting allergy trials that compare R112 with
steroids,” he said. “We’re looking to show equal symptom
improvement and a faster onset of action. Steroids take a couple
of days to kick in. In our last Phase II, we had onset of action
within 30 minutes.”
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