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Strategies & Market Trends : Ask Vendit Off-Topic Questions
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To: Jill who wrote (5582)2/28/2005 6:23:05 PM
From: Walkingshadow  Read Replies (1) of 8752
 
<<This whole idea of blocking inflammatory pathways is misguided imo. Period. We need inflammation in order to fight pathogens. >>

I don't think it is misguided.

We need inflammation to fight pathogens, but the problem is that inflammation can be inappropriately turned on in the absence of infection, and can remain on... a loose cannon on the gundeck.

The result is the host of diseases whose predominant feature is chronic inflammation... inflammatory bowel disease, arthritis, Alzheimer, atherosclerosis (heart attacks and strokes). In short, the diseases that are responsibile for the majority of global death and disability.

You might be surprised at how efficient innate immune mechanisms are at destroying pathogens, even when the system is severely compromised. There are a lot of backup mechanisms and redundancies built into host defense. Most of what the immune system is doing never comes to your attention because it never causes symptoms, but suffice it to say that literally 24/7, there are battles going on all over your body because pathogens commonly and continuously find their way into places they don't belong. It is nonstop.

Just because some anti-inflammatory drugs cause adverse effects is no reason to throw the baby out with the bath water, much less decide to stop bathing the baby ever again.

T
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