XOMA Awarded $15 Million Contract from NIAID to Help Fight Bioterrorism
Thursday March 10, 5:44 pm ET
XOMA to Develop Three Anti-Botulinum Neurotoxin Monoclonal Antibodies
BERKELEY, Calif.--(BUSINESS WIRE)--March 10, 2005--XOMA Ltd. (Nasdaq:XOMA - News) today announced that it was awarded a $15 million contract from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH), to produce three botulinum neurotoxin monoclonal antibodies designed to protect U.S. citizens against the harmful effects of biological agents used in bioterrorism.
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Under the 18-month contract, XOMA will develop monoclonal antibody therapeutics using proprietary antibody expression systems to produce anti-type A-botulinum neurotoxin monoclonal antibodies including a Master Cell Bank (MCB), Manufacturer's Working Cell Bank (MWCB) and other designated deliverables. The antibodies will be produced under Good Manufacturing Practices (cGMP) at XOMA's manufacturing facility. This project will be 100% funded with Federal funds from NIAID under Contract No. HHSN266200500004C. SRI International, an independent, nonprofit research institute based in Menlo Park, CA, will be a subcontractor under this contract and will develop potency assays to support antibody characterization.
"Numerous events in the United States over the past few years serve as a stark reminder that the use of biological agents remains a real threat," said John L. Castello, president, chairman and CEO of XOMA. "As an industry leader in developing monoclonal antibodies, XOMA is committed to working with the U.S. government to develop new therapies to counter these biological threats."
"We have previously stated that an important part of our strategy for achieving profitability is increased utilization of our process development and manufacturing assets," continued Castello. "This contract with NIAID is an important step forward in achieving this objective."
About Botulism Neurotoxin (BoNT)
With the recent deliberate exposure of postal workers, other government employees, and the American public to Bacillus anthracis spores, there is an urgent need to devise effective measures to protect U.S. citizens from the harmful effects of biological agents used as instruments of terror. Botulinum neurotoxins are one of these biological threats and new vaccines, therapies and diagnostics are needed to counter the potential terrorist use of these toxins.
About NIAID
NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at niaid.nih.gov.
About SRI
Silicon Valley-based SRI International (www.sri.com) is one of the world's leading independent research and technology development organizations. Founded as Stanford Research Institute in 1946, SRI has been meeting the strategic needs of clients for almost 60 years. The nonprofit research institute performs client-sponsored research and development for government agencies, commercial businesses and nonprofit foundations. SRI's Biosciences Division works with government agencies and commercial pharmaceutical and biotechnology companies to provide a broad range of preclinical drug discovery and development services, including medicinal chemistry, custom synthesis, regulatory support, efficacy and safety evaluations, pharmacokinetics and metabolism studies, analytical chemistry and formulation design in production in GLP and cGMP environments. The division specializes in cancer, infectious disease and neurobiological research.
About XOMA
XOMA develops and commercializes antibody and other protein-based biopharmaceuticals for cancer, immune disorders and infectious diseases. The company pipeline includes products from collaborative product development programs with Chiron Corporation, Millennium Pharmaceuticals, Inc., and Aphton Corporation. For more information about XOMA's product pipeline and antibody product development capabilities and technologies, please visit XOMA's website at xoma.com. |
