>>J Chromatogr B Analyt Technol Biomed Life Sci. 2005 May 5;819(1):59-66.
Peptide profiling in epithelial tumor plasma by the emerging proteomic techniques.
Caputo E, Lombardi ML, Luongo V, Moharram R, Tornatore P, Pirozzi G, Guardiola J, Martin BM.
Institute of Genetics and Biophysics-I.G.B., A.Buzzati-Traverso, CNR, Via G. Marconi 10, I-80125 Naples, Italy; Unit on Molecular Structures, NIMH, 10 Center Drive Bldg103N309, Bethesda, MD 20892-1262, USA.
The plasma peptide component (PPC) from ten melanoma (Mel), breast cancer (BC) and healthy individuals was examined by a combination of RP-HPLC, surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and tandem mass spectrometry. A three peak pattern (2023, 2039, 2053.5 m/z) was primarily observed in melanoma. Two peaks (2236.1 and of 2356.3 m/z) were found only in BC samples. Fibrinogen alpha and inter-alpha-trypsin inhibitor heavy chain H4 fragments were absent in both tumor samples.<<
That last sentence is interesting, because inter-alpha-trypsin inhibitor heavy chain h4 seems to be one of the markers for ovarian.
Cheers, Tuck |
