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Biotech / Medical : American Pharmaceutical(APPX)
APPX 36.58+5.6%Oct 31 9:30 AM EST
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From: MLD384/19/2005 2:39:38 AM
   of 22
 
Abraxane (ABI-007) vs taxotere: (etc)
a preclinical comparison of toxicity and efficacy
abstractonline.com{4BD9D8A1-F768-4BCC-A1BA-B894A7CA8CB6}&MKey={218FF7E7-9F17-4030-9BB4-8C029B0C9B4E}&AKey={728BCE9C-121B-46B9-A8EE-DC51FDFC6C15}&SKey={030AEAEC-4564-442F-B427-563A35B18B38}
Conclusion: Nanoparticle abumin-bound paclitaxel (Abraxane) was superior to Taxotere in the MX-1 tumor model when tested at equal doses. Furthermore, the toxicity of Abraxane was significantly lower than that of Taxotere, which would allow dosing of Abraxane at substantially higher levels. These results are similar to the enhanced therapeutic index seen with Abraxane compared to Taxol and suggest that the presence of surfactants may impair the transport, antitumor activity and increase the toxicity of taxanes. Studies in additional tumor models comparing Abraxane and Taxotere are ongoing.

Thanks for the link goes to hobiz2 on Yahoo's APPX board:
Go to this website :www.abstractonline.com/viewer/?mkey=%7B218FF7E7-9F17-4030-9BB4-8C029B0C9B4E%7D
then simply plug in the numbers of the abstracts
1437
1432
1435
2390
3439
2988
3007
5584
and hit search presentations. It will give you a pop-up window with the abstract and a button to click to print it out.
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