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Biotech / Medical : SIBIA Neurosciences (SIBI)

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To: scaram(o)uche who wrote (71)	9/6/1997 12:29:00 AM
From: Frank Stein	of 579

Rick: I offer you my sincerest apologies....you posted the PNAS link due to the "significant and relevant discussion of acetylcholinesterase inhibitors and the pathophysiology of disease"...... i thought you posted it "regarding the concept behind the "53 series"..... Again, it was silly for me to think that the 53 series comprised acetylcholinesterase inhibitors when they are Nicotinic agonists....again...i apologize.... i understand that you are not a neurologist....that you have acknowledged ignorance in the field of neuroscience....For you, "It's difficult to deal with bluster in the context of comments that demonstrate holes in experience." .....(post number 45)....I on the other hand find it quite entertaining....yes ....you make this thread more entertaining than "Seinfeld" Despite you ignorance in Neurology....you ramble on with Supreme Authority.... As best as i can tell....you rely on so-called experts to lend credence to Sibia's approach to an Alzheimer's drug....and you have dumped abstracts on this thread as well....seems to me...Correct me if i am misunderstanding you again.....that you have offered no Cellular/Molecular data to support Sibi'a approach....and you have offered some circumstantial systems evidence.... So the muscarinic acetylcholine recptor is expressed in the hippocampus....i will go out on a limb and say that Actin is also expressed in the hippocampus....Hmmm...if that's true.... well then actin must play a significant role in learning and memory....and it simply must be the culprit behind AD... I think i will go out and make drugs to target actin....start a company with a nice story behind it....Actin Based Therapy For Alzheimer's Disease.... I think Muscle cells also express acetylcholine receptors...Hmmm...perhaps muscles are involved in Alzheimer's disease as well....Yet another idea for an Alzheimer Biotech company that Wall Street will fall in love with! Cheers! Frank

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