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Biotech / Medical : ACADIA Pharmaceuticals Inc (ACAD)

ACAD 25.88

+1.7%

Dec 3 3:59 PM EST

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From: scaram(o)uche	5/22/2005 2:31:13 PM
	Read Replies (1) of 588

HIGH TROUGHPUT FUNCTIONAL ASSAY FOR G-PROTEIN COUPLED RECEPTORS USING A RAP-RAS CHIMERIC PROTEIN Patent number: WO2005042574 Publication date: 2005-05-12 Inventor: BURSTEIN ETHAN S (US); PIU FABRICE (US); MA JIAN-NONG (US); WEISSMAN JACQUES THOMAS (US); WEINER DAVID M (US); SCULLY AUDRA L (US); NASH NORMAN (US); SPALDING TRACY (US); CURRIER ERIKA (US) Applicant: ACADIA PHARM INC (US);; BURSTEIN ETHAN S (US);; PIU FABRICE (US);; MA JIAN-NONG (US);; WEISSMAN JACQUES THOMAS (US);; WEINER DAVID M (US);; SCULLY AUDRA L (US);; NASH NORMAN (US);; SPALDING TRACY (US);; CURRIER ERIKA (US) Application number: WO2004US36595 20041102 Priority number(s): US20030517143P 20031103 Abstract of WO2005042574 Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes. In some cases, chimeras linking the regulatory domain of the rap1B protein to the effector region of the ras oncogene are used in conjuction with existing functional assays for cellular proliferation. Furthermore, overexpression of other genes can further augment the enabling properties of ras/rap chimeras.

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