Illumina Launches Industry's First SNP Assay Panels for Fine Mapping Disease-Associated Genetic Variants in the Major Histocompatability Complex -MHC- Region of the Genome
Tuesday June 7, 6:00 am ET
High-Density Panels Are Designed to Enable Identification of Genes Associated with Autoimmune and Inflammatory Disorders
SAN DIEGO--(BUSINESS WIRE)--June 7, 2005-- Illumina, Inc. (NASDAQ:ILMN - News) announced today the commercial availability of two single nucleotide polymorphism (SNP) - based assay panels designed to study genetic variation and function in the MHC region (see Note) of the human genome. The MHC is rich in gene content and genetic diversity, and the region is believed to contribute to the majority of common autoimmune and inflammatory disorders including multiple sclerosis (MS), Type-1 diabetes and rheumatoid arthritis.
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Illumina's new panels represent the industry's first-ever MHC-focused SNP panels for high-throughput, array-based analysis. By conducting high-resolution analysis of the MHC across many samples, life science researchers may be able to determine some of the key genes and genetic variants that lead to disease susceptibility. The MHC Exon-Centric Panel consists of 1228 SNPs in or within 10kb of protein-coding regions (exons), while a companion MHC Mapping Panel includes 1,293 SNPs evenly distributed across the entire region.
Illumina has optimized its MHC SNP sequences for the Company's GoldenGate(TM) genotyping protocol, a high-performance assay method validated by hundreds of millions of genotypes. The MHC panels are used in conjunction with the Company's universal arrays, which are available in two bead-based, multi-sample platforms: the Sentrix® Universal-96 Array Matrix and the Sentrix Universal-16 BeadChip, both of which can be imaged on Illumina's BeadArray Reader.
"The MHC is one of the most difficult regions to study due to the high degree of genomic variation," explains Sarah Shaw Murray, Ph.D., Staff Genotyping Science Manager. "Our fine-mapping SNP panels have the potential to provide answers and/or important clues to many unresolved biological mysteries residing in the MHC."
The new MHC panels can be purchased as a standard product -- separately or as a set -- by research facilities which have installed Illumina's BeadStation or BeadLab genotyping systems. The panels may also be ordered as part of Illumina's fast-track genotyping service. Depending on study size, running costs per sample (array and reagents) can be less than $100. More information about the MHC panels can be found at: 10.10.3.242 .
"Our MHC panels represent a powerful new tool for geneticists," stated Jay Flatley, Illumina President and CEO. "For the first time, we're enabling highly focused MHC studies and giving researchers experimental flexibility by making the SNP panels available on two different Sentrix platforms which can accommodate a range of sample throughputs with very attractive per-sample price points. We plan to add at least two more focused genotyping offerings before the end of the year."
Illumina's genotyping product portfolio includes custom and standard products, with focused and whole-genome content, deployed on two different array platforms: the 96-sample Sentrix Array Matrix and the Sentrix BeadChip.
Illumina (www.illumina.com) is developing next-generation tools that permit large-scale analysis of genetic variation and function. The Company's proprietary BeadArray(TM) technology -- now used in leading genome centers around the world -- provides the throughput, cost effectiveness and flexibility to enable researchers in the life sciences and pharmaceutical industries to perform the billions of tests necessary to extract medically valuable information from advances in genomics and proteomics. This information will help pave the way to personalized medicine. |
