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Biotech / Medical : dsco Discovery Laboratories
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To: Arthur Radley who wrote (63)6/9/2005 6:03:32 PM
From: Arthur Radley  Read Replies (1) of 318
 
This from a Yahoo poster today ..
We know from our experience in babies that Pulmonary Surfactants are very potent anti-inflammatory agents without all the harmful side effects of Gluco-Corticoids (steroids). Add to this that the primary defect in an asthmatic lung during wheezing is failure of the terminal airway to stay patent (open)because of excessive surface tension, Surfaxin delivery to this distal airway may be sufficient to overcome collapse and break the asthmatic vicious cycle of air trapping and hypoxia. Asthma incidence, mortality, and morbidity have been consistently on the rise in industrialized nations, and current therapies have been unsuccessful to stem the tide. Aerosolized Surfaxin as outpatient therapy, in the ER for an acute attack, or instilled directly into the lung of a critically ill asthmatic patient in the ICU, may all prove to be applications for "precision engineered" products with different KL4 protein to phospholipid ratios. We have been unable to explore these therapies in the past due to the expense, infectious, & immunogenic issues involved in the animal derived products, and the therapeutic failures of the synthetic products that don't contain Surfactant Protein. This only adds to the block-buster potential of Surfaxin if treatment in only some of these multi-billion $ indications turns out to be successful. JMHO.
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