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Biotech / Medical : Cell Therapeutics (CTIC)

CTIC 9.090

0.0%

Jun 26 5:00 PM EST

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To: Ian@SI who wrote (695)	6/15/2005 6:41:10 PM
From: Extra Pale	of 946

Series of interesting posts on yahoo MB by an individual claiming to be one of the significant designers of the pix molecule. Points out that the design of pix was focused on reducing toxicity not increasing effectiveness. Interesting posts such as the following: Re: pixantrone by: bbr2778vt 06/15/05 12:50 pm Msg: 34514 of 34518 I really dont know how to make this ANY clearer- when you design a drug you DON'T know if it is going to be better or not!!! We designed the drug to make the drug less cardiotoxic and we hoped that it would be more effective. Now pay attention here PLEASE!!! We do not know if it has better anti-umor activity until it gets large scale testing in humans. The fact that PIX lacks cardiotoxicity makes it a far better drug already!! AGAIN, please pay attention- it was I who suggested removal of the OH group would decrease the cardiotoxicity and it was the chemist who was able to make the drug by making the chromophoe backbone a heterocyclic compound rather than the carbocyclic backbone seen in MITO and DOX. The introduction of the aza- nitrogen eliminated the need of the OH group and provided the drug its anti-tumor activity that surpassed that of MITO - IN ANIMAL MODELS!!!!! I only wanted to straighten out the record on the PIX discovery story - I didnt intend to get involved in a discussion about my scientific knowledge and intergrity. If you want to discuss science I would be more than happy to discuss it elsewhere!!!

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