momo-T/FIF Message Board

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : momo-T/FIF

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next

To: scaram(o)uche who wrote (2930)	8/10/2005 6:46:54 PM
From: tuck	Read Replies (3) of 12215

Off Topic Science question for ya, Rick (others who feel qualified may chip in). You've worked with antibodies, so maybe you can help. Prealbumin or transthyretin (TTR) has two binding sites. These are not on the n-terminal. They're in the binding channel that runs down the center of the tetramer. Suppose you've got a serum sample you want to assay for a fragment of TTR that has had its n-terminal lopped off (i.e. the fragment you want has the binding site). Could one design an antibody that would allow an immunoassy (specifically, an ELISA) to find only that fragment, and not whole TTR or other isoforms thereof? I'd guess cross-reactivity with these other forms is going to doom an immunoassay approach. TIA for any help, and Cheers, Tuck, who is off to climb and drink beer, in that order.

Report TOU Violation

Share This Post

Public Reply Prvt Reply Mark as Last Read File

Previous 10 Next 10 Previous Next