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Biotech / Medical : The thread of life
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To: Mike McFarland who wrote (814)9/27/2005 9:50:19 PM
From: Mike McFarlandRead Replies (1) of 1336
 
just some stuff that is more readable,
fwiw

Mr. Slow Glass, a somewhat futile effort to catch up
on the jargon...

sciencemag.org

Phage display takes advantage of the genetic structure of the bacterial virus (or phage) M13, and the way that this virus builds its protein coat. M13 has a protein with which it decorates its surface as it grows. The developers of the phage display method discovered that they could insert foreign (that is, non-M13) proteins into the M13 protein, which would then carry them to the phage surface and display them, just as if they were M13 proteins, while the DNA encoding the displayed protein is contained within the phage virion. This allows rapid identification of selected sequences by DNA sequencing. Phage displaying a given polypeptide sequence can be specifically captured from vast pools of displayed sequences via an in vitro affinity interaction with an immobilized target specific for that sequence. Individual tight-binding ligand sequences can be identified from a pool of several billion displayed sequences in only a few days.



This one crams a lot of jargon into maybe not such
a good paper, but I guess I will skim it
bentham.org

Sorry for the excessive flurry of activity this afternoon.
It just again confirms that there is an awful lot more to
these companies that I don't appreciate beyond the basic
book valuation. This started with "Libraries from natural
product-like scaffolds". Don't know where it will take me.
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