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Biotech / Medical : Kosan BioSciences -- KOSN

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To: Icebrg who wrote (608)	10/8/2005 7:22:48 AM
From: Mike McFarland	of 933

recent theoretical study has revealed that modular PKSs (such as the erythromycin PKS) have the potential to generate hundreds of millions of compounds through reassembly of the catalytic units in novel combinations. This is a staggering number compared with the 10,000 polyketides described from all natural sources. The Lego-ization of polyketide biosynthesis David H Sherman nature.com Theoretical Considerations and Computational Analysis of the Complexity in Polyketide Synthesis Pathways Joanna González-Lergier, Linda J. Broadbelt, and Vassily Hatzimanikatis pubs.acs.org ...experimental approaches to engineer novel polyketides, a number of which will likely have medicinal properties

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