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Biotech / Medical : SARS and Avian Flu
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To: Think4Yourself who wrote (2694)10/14/2005 10:07:28 PM
From: Elroy Jetson   of 4232
 
What I hoped to say, using hopefully plainer language now, is:

a.) Only a tiny minority of diseases accidentally create a molecule whose shape triggers an immune system response, so forceful that it is counter-productive;

b.) This overly strong immune response is what some people call a "cytokine storm", although most call this a super-antigen response;

c.) This overly forceful response by the immune system can often, but not always, be quickly brought under control with immune suppressive drugs;

d.) This IL-1 (a type of cytokine) driven response to super-antigens can be totally and completely reversed with IL-7 (another type of cytokine), although IL-7 is not approved for human use (although, ironically, it is produced by your immune system) but it is available through a biological supply house;

e.) There appears to be precious little evidence that the H5N1 virus causes a hyper-antigen response (aka a cytokine storm). All of the H5N1 symptoms are consistent with a virus which infects and destroys the lungs;

f.) Interferon-alpha (Roferon or Intron-a) should direct the immune system to maintain an effective Natural Killer cell immune response, even if immune suppressive drugs are used to turn off a super-antigen response (aka cytokine storm).
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