You, not me, cited the TNF reference in response to my comment re. your "antigen" post.
So, let's take it one step down the ladder to make it easier for you........ NO monoclonal of ANY nature against antigens from pathogens OR against any endogenous cytokine has been shown to be effective for sepsis. In addition to E5 and HA-1A and among that broad class, both anti-IL-1 and anti-TNF have FAILED in trials.
It is extremely easy to produce MAbs which are protective in animal models of sepsis, paired MAb and pathogen. I've personally produced hundreds of protective MAbs to P.aeruginosa and P. mirabilis. But there is no single antibody that provides protection in the real-world setting, where zillions of serotypes are encountered.
You don't have the knowledge that you're posturing to have. No sweat, but I'll definitely continue to point out that your "posture as informed" posts are largely full of crap. It would be easier if you'd just stop, but...... whatever.
>> I have no idea where you developed the idea that TNF is the super-antigen <<
That makes two of us. Maybe that's because I never said -- or even dreamed of -- anything quite so silly.
>> TNF is a cytokine created by the immune system in response to a super-antigen, not an antigen. <<
Wrong, yet again. But, yes, plenty is produced in response to a super-antigen. |
