Avian ("Bird") Flu Stocks Message Board

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Biotech / Medical : Avian ("Bird") Flu Stocks

NNVC 1.850

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Nov 7 9:30 AM EST

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To: Becky who wrote (71)	10/23/2005 8:52:24 PM
From: cari	Read Replies (1) of 428

Yes, there was a strain that was found to be resistant. But that isn't what you stated when you said the following: "I believe tamiflu is ineffective against BF" and "Tamiflu is for a totally unrelated flu"? It also doesn't explain what you meant by: "I believe Tamiflu IS ineffective against BF. That's Y there's no vaccine at this time." There's a difference between an ineffective drug and an effective drug to which strains of viruses have developed resistance to. What that has to do with why there's no vaccine at this time is unclear to me. If you continue with the article you gave a link to, it says: Yesterday's report is the first indication that tests have detected a drug-resistant strain of H5N1 since the virus began circulating among birds in Asia. It was found in a 14-year-old Vietnamese girl who became ill in February while caring for her brother, who was also infected. She had initially received a low preventive dose of Tamiflu, and then a higher dose when she became ill. She recovered fully... Genetic fingerprinting of the resistant strain suggests that the girl was infected by her brother, as their viruses were extremely similar. But it appears that the resistance developed in the girl. Drug-resistance mutations in viruses are rare and arise by chance. When they occur in the presence of a drug, however, a resistant strain can become dominant through natural selection as susceptible strains are killed off. The girl harbored three strains -- one resistant to oseltamivir, one partially resistant and one susceptible. All three were probably descended from the single strain that initially infected her. Tamiflu resistance has appeared in other strains of the influenza A virus, the broad family that includes H5N1. Japanese researchers reported last year that in a small group of children treated with Tamiflu, 18 percent developed resistant viruses.

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