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Microcap & Penny Stocks : 10-Bagger MINIMUM Rise from July 1, 2005 until December 31,
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To: Jill who wrote (683)10/26/2005 1:46:58 AM
From: Walkingshadow  Read Replies (1) of 1694
 
The TLR signaling network is "shaped" like an hourglass.... at the top of the hourglass are the ligands.... thousands of them, likely tens or hundreds of thousands.

Then it cinches down to the receptors, 10 or 12 or so, depending on the species. And they can combine with one another.

Then it cinches down more to the adaptors.... really about 4 or 5 of them, that is the first intracellular part.

Next is a set of kinases called IRAKs, and there are just 2 of them so far as we know. That's the narrowest part of the hourglass.

Then it spreads out again to the various downstream subpathways ending in activation of NF-kB, IRF3, etc.

Then it spreads out still further, until finally at the farthest end you have the gene targets, which number in the hundreds at least.

Maybe that helps in seeing why it is hard to "block" the whole system. The only way you could do that would be to target the "choke point". Anything else will block (or accelerate) just side branches or portions of the network to various degrees.

I think it would pay to keep our eyes open..... lots of pharmas and biotechs are on to this big time. They know there's products there for sure, they are hot on the trail. It has really just begun, there will be a lot of money to be made there.

T
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