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Strategies & Market Trends : Mish's Global Economic Trend Analysis
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To: Casaubon who wrote (40325)10/31/2005 10:01:04 PM
From: Elroy Jetson  Read Replies (2) of 116555
 
Mice infected with a fatal strain of the H5N1 virus circulating in Vietnam were given a five-day course of oseltamivir (Tamiflu) at amounts roughly equivalent to a human dose. Half died. In previous experiments, treated animals infected with the Hong Kong strain all survived.

But when mice with the Vietnam virus were treated for a longer period -- eight days -- 80 percent survived.

washingtonpost.com

This indicates that the development of an effective immune response against H5N1 in mice is roughly eight days.

Tamiflu still needs to be given within the first few days to prevent widespread infection and cell destruction, but having halted the viral replication to a crawl, mice need continued viral containment by the drug for eight days. By that time the immune response is sufficient to withdraw the drug.
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