David:
OK, you can be a lunatic if you get him to change my focus to long-term with near-term enthusiasm.
53% (dry mouth), and my market figures are going up..........
Ryumachi 1997 Jun;37(3):453-457
Treatment with pilocarpine hydrochrolide for sicca
symptoms in Sjogren's syndrome.
Takaya M, Ichikawa Y, Yamada C, Hoshina Y, Horiki T, Uchiyama M
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.
We studied the efficacy of oral pilocarpine hydrochrolide (9 mg/day, three times daily) on sicca
symptoms in 21 patients with Sjogren's syndrome (SS) of the patients, 19 continued the treatment
for at least one month, and subjective improvement of dry mouth and dry eye was observed in 10
patients (53%) and 5 patients (26%), respectively. As adverse effects, diaphoresis was most
frequently recognized, but it was generally mild and tolerable. In the four patients who have been
taking pilocarpine for 12 months, any severe side effects have not been observed. Since the
incidences of clinical improvement of sicca symptoms and adverse effects were comparable with
the other studies reported from US or Europe, our treatment protocol using pilocarpine
hydrochrolide (9 mg/day) was considered as appropriate for Japanese SS patients. |
