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Biotech / Medical : Sangamo Therapeutics, Inc. SGMO

SGMO 0.428

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From: earnieX	11/27/2005 10:22:14 AM
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Good results... RICHMOND, Calif., Nov. 16 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO - News) today announced that data from its program to develop a ZFP Therapeutic(TM) for congestive heart failure (CHF) were presented at the Scientific Sessions of the American Heart Association (AHA) on November 16, 2005, in Dallas, Texas. Sangamo's collaborator Frank Giordano, M.D., Associate Professor of Cardiology at Yale University School of Medicine, presented the data in the Gene Expression/Molecular Biology II session in which he also served as co-moderator. The data presented demonstrate that Sangamo has designed zinc finger DNA- binding protein transcription factors (ZFP TF(TM)) that repress the expression of the phospholamban (PLN) in human cells and in rat cardiomyocytes with singular specificity. When administered directly into the heart of adult rats a ZFP TF PLN repressor was shown to improve cellular calcium flux and enhance both the rate and extent of relaxation and contraction of the heart muscle cells. Moreover, in a rat model of heart failure, treatment with Sangamo's ZFP TF PLN repressor demonstrated improved contractility and hemodynamics or blood movement into and out of the heart. "We are very excited by these data," said Dr.Giordano. "PLN is a critical regulator of cardiac homeostasis and muscle contractility and has been well- validated in a number of animal models as a target for congestive heart failure. However, the conventional approach of developing small molecule antagonists of PLN has proven to be very difficult. Sangamo's technology provides a novel approach which has the potential to address the molecular root of the disease and may provide improvement in contractility in failing hearts regardless of the origin of the disease."

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