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Biotech / Medical : Rigel Pharmaceuticals, Inc. (RIGL)
RIGL 37.87+33.8%Nov 5 3:59 PM EST

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To: kenhott who wrote (285)12/5/2005 12:27:17 PM
From: tuck  Read Replies (1) of 566
 
Did you in fact listen to the CC? I would recommend doing so. It seems to be more of a matter of potency & perhaps formulation (relating to various matters of PK/PD such as bioavailability, concentration, and so on) of the compound than validity of the target. This suggests follow-on compounds -- one of which is supposed to be 30x more potent -- have a decent chance.

Further, the biology of RA is very different, and the compound aimed at it is systemic, while R112 for rhinitis was not.

No, I think the target is fine, but the first shot on goal just went wide. Now, comments regarding how early the pipe is are nevertheless on target. We'll hear more about that on the 15th.

I haven't attempted a valuation analysis, but if lots of people are thinking that Syk is a bad target, then Rigel may have been beaten up a bit too much.

Cheers, Tuck
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