To Bernie, Kingfisher and all:
This memo was faxed to Dr. H this am.
To: Dr. Hirschman
From: Joe Scotti
Date: September 15, 1997
Subject: University of Texas
Dear Dr.
One of our very astute shareholders has posted this very interesting article on cytokine gene transcription authored by Ye J, Young on September 11, 1997 on one of the Internet Investment sites.
Does this research paper relate to the work you are doing on Reticulose? Many fellow shareholders would like to know if there is a connection. Your prompt response is greatly appreciated. As always, you can reach me by telephone at 603.xxx.xxx.
FASEB J 1997 Sep;11(11):825-833
Negative regulation of cytokine gene transcription.
Ye J, Young HA
Department of Cellular and Structural Biology, University of Texas Health
Science Center at San Antonio, 78284, USA.
Cytokines are a class of soluble proteins that mediate signals throughout
the immune system as well as between immune effector
cells and other cell populations. This class of proteins includes
interleukins, interferons, and chemokines. The expression of
cytokines is tightly controlled in the producing cells, and one of the most
important regulatory steps in this control is gene
transcription. The transcription of most cytokine genes is silent until a
producing cell is activated by extracellular stimuli. It is
very common that transcription of these genes initiates immediately upon
activation and shuts down quickly even in the
continuous presence of the stimulating agent. Work performed over the past
decade has revealed much about the molecular
mechanism responsible for transcriptional regulation of these genes.
Positive and negative transcription factors function in a
concerted manner to regulate transcription of a specific cytokine at the
promoter or intron region. We focus on recent progress
in the field of transcriptional regulation of cytokine genes with an
emphasis on the negative regulation of cytokine gene
transcription.
PMID: 9285480, MUID: 97429842 |
