Novel Interferon Signaling Pathways Explored in Special Issue of Journal of Interferon & Cytokine Research
NEW ROCHELLE, N.Y.--(BUSINESS WIRE)--Dec. 28, 2005--The multiple signaling pathways used by the group of cytokines commonly known as interferons to alter the body's immune system and exert their antiviral and growth inhibitory effects include many newly discovered signaling elements and mechanisms that are redefining the view of how interferons function and are described in a cutting-edge Special Issue (December, Volume 25, Number 12) of Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. Several key papers are available free online at www.liebertonline.com/jir.
Dedicated to Neo-Classical Pathways of Interferon Signaling, the December Special Issue of the Journal takes an in-depth look at recent research efforts to identify and characterize the interactive, cooperative signaling networks that are helping shed light on the complex mechanisms by which interferons regulate gene expression and affect the function of immune cells.
Guest Editor Leonidas C. Platanias, Ph.D., has gathered an impressive collection of papers prepared by experts in the field that spans the many aspects of interferon signaling.
"The emerging evidence from all these discoveries suggests that the cooperation among multiple signaling elements and pathways is essential for the induction of IFN-responses, and is in a way transforming again the field of IFN-signaling," writes Dr. Platanias.
The Journal includes an article by Inna Nusinzon and Curt M. Horvath entitled,
"Unexpected Roles for Deacetylation in Interferon- and Cytokine-Induced Transcription,"
in which the authors present evidence to support the theory that positive regulation of gene expression by interferons and other cytokines requires both acetylation and deacetylation.
Efstratios Katsoulidis and colleagues describe recent findings on the role of the p38 MAP kinase pathway in mediating IFN-dependent biological effects and discuss the impact of upstream and downstream pathway components on the control of cellular responses triggered by interferons in an article entitled,
"The p38 Mitogen-Activated Protein Kinase Pathway in Interferon Signal Transduction."
Focusing on one particular signaling pathway used by interferon to regulate gene transcription, Dhananjaya V. Kalvakolanu and Sanjit K. Roy describe the use of a phosphorylation/dephosphorylation mechanism to activate interferon-stimulated genes in the article entitled,
"CCAAT/Enhancer Binding Proteins and Interferon Signaling Pathways."
"The authors of the articles in this issue have made significant recent discoveries that will help us understand better how interferons work," says Ganes C. Sen, Ph.D., Professor, Department of Molecular Genetics, Cleveland Clinic Foundation and Co-Editor in Chief of Journal of Interferon & Cytokine Research.
"The new information will be valuable for designing optimum protocols for clinical use of interferons in treating various diseases."
Journal of Interferon & Cytokine Research, edited by Ganes C. Sen, Ph.D., and Thomas A. Hamilton, Ph.D., Chairman, Department of Immunology, Cleveland Clinic Foundation, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications.
Journal of Interferon & Cytokine Research is the official journal of the International Society for Interferon and Cytokine Research. Tables of contents and a free sample issue may be viewed online at www.liebertpub.com/jir.
Mary Ann Liebert, Inc., is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including AIDS Research and Human Retroviruses, Cancer Biotherapy & Radiopharmaceuticals, and Viral Immunology.
Its biotechnology trade magazine, Genetic Engineering News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 60 journals, books, and newsmagazines is available at www.liebertpub.com.
Key(s): kinase signaling pathways signaling pathway gene expression immune cells
omniomix.com
Note:Not certain I posted to correct or best applicable
board. If not, please post to other appropriate boards. |
