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Biotech / Medical : Kosan BioSciences -- KOSN
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To: mopgcw who wrote (639)1/7/2006 6:06:02 PM
From: zeta1961  Read Replies (1) of 933
 
thanks George for your milestone update..I found this private company while doing homework for JPMorgan..parking here in case it might be useful..

Best!..Elisabeth

disclosure: missed KOSN's big run last year:-( but in my charity and will be in my ASCO 'folio

IPI-504, Infinity’s proprietary Hsp90 inhibitor, is in Phase I clinical trials and has the potential to treat a broad range of cancers, including those that are resistant to other drugs

Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. It functions to allow a cancer cell to survive despite an abundance of mis-folded and unstable proteins. Hsp90 also stabilizes oncogenic proteins that enable cancer cells to survive and proliferate, including cancers that are resistant to other drugs. Inhibition of Hsp90 has broad therapeutic potential for the treatment of patients with solid tumors and hematologic cancers.

IPI-504 is Infinity’s novel, proprietary agent that potently and selectively inhibits Hsp90. It has demonstrated efficacy in multiple animal models of cancer as a single agent as well as in combination with existing anti-cancer drugs. IPI-504 preferentially targets and accumulates in tumor tissues, sparing healthy tissues. IPI-504 is delivered in a patient-friendly, water-based formulation.

Phase I clinical trials with IPI-504 were initiated in July 2005.

ipi.com

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