Geeze, I made that bottle of Provigil last
for a year and a half! Needless to say,
I supplemented it with a lot of Coffee.
Anyway, I thought this was interesting and I don't
know of a combichem thread, so this is as good as anywhere.
Microwaves Make Combichem Really Cook
dddmag.com
At Cephalon Inc., Frazer, Pa., Blanca Martinez, PhD, is setting up a new hit-to-lead discovery group using the newest microwave reactors as a core technology. Martinez, impressed with microwave heating from her experiences at Adolor Corp., Exton, Pa., considers microwaves indispensable in the laboratory. "Once you've tried it, there's no reason to go back. When I was at Adolor, we wouldn't even try reactions under traditional conditions anymore. The microwave was our starting point." Martinez prefers the term parallel synthesis to describe the work her team does in taking results from high-throughput screening and bringing them forward to lead development for medicinal chemistry. "Combinatorial chemistry got sort of a bad reputation in the past few years. The first combinatorial libraries that were made were of low quality, with higher numbers of compounds, but very little information about the purity of each compound. The field has evolved." Even so, she says her peers have been slow to adopt microwave synthesis. "It's taken a little bit [of time] to spread. There's a certain kind of chemist that is a little traditional in the way they do things. If I've done things in a certain way and I know it works, there's a reluctance to change."
CEPH sure looked like a good one to swing trade these past five years:
finance.yahoo.com |
