Zonagen (zona) - good buy? Message Board

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Biotech / Medical : Zonagen (zona) - good buy?

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To: Tokyo VD who wrote (551)	9/17/1997 12:48:00 AM
From: Bruce Rosen	of 7041

gls writes: <<This study gave you 4 chances in 10 of coming up to performance standards...and you may have to wait an hour and a half to find out if this is your lucky night. .>> One point that has not been made here is that it is not a random shot as to who will be helped by Vasomax. Open label studies confirm that about 25 to 30% of men continue to get significant benefits over the long term and remain as regular users. Once you try it, you will know if it works for you. A 25% market share would be a home run for Zonagen. Time of onset for Vasomax is 15 - 30 minutes. In response to this:<<The Pfeizer oral administration has more serious side effects.>> +++gls says: <<That is an interesting observation. I have tried to do some internet research and medline work on that aspect but I'm coming up short. Can you direct me to info on this aspect?>> In the AUA conference held this past spring, Pfizer released the following statistics regarding side effects of Viagra at the most efficacious 100 mg. dose: Headaches - 11%; Stomach Upset - 8 1/2%; Vascular Flushing - 8 1/2% Vasomax, at its optimal dose of 40 mg. has virtually no side effects. Tokyo VD says: <<Zonagen's efficacy was predicated upon men whose ED was only mild to moderate. The trials clearly showed that the drug had no effect on men with moderate to severe ED.>> In the U.S. phase 3 trials, 98% of the men tested had organic causes, with some suffering from heart disease, diabetes and other ailments. The only excluded causes were severe spinal cord injuries and radical prostectomies. Zonagen actually screened a more severely impotent population than Pfizer. Tokyo VD also says:<<The Zonagen study endpoint was based on IIEF scores, not the intercourse endpoint utilized by Vivus and Pharmacia-Upjohn. As for the secondary scoring of intercourse from the Zonagen created SEP (Sexual Experience Profile), well that has yet to be statistically validated>> The IIEF endpoints and the secondary endpoints were constructed with FDA guidance. Pfizer followed the IIEF guidelines as well. Zonagen's secondary endpoints were actually more stringent than Pfizer's, Zona's being successful intercourse while Pfizer's being an erection sufficient for intercourse. Whichever guidelines you use, Vasomax passed with flying colors. I would hate to be short this stock when a deal with a major pharma is announced!

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