2005 - 3 cases of Memantine helping with schizophrenia
TRANSLATED BY GOOGLE ....
Brazilian magazine of Psychiatry
Print?ISSN?1516-4446
?
Rev. Bras. Psiquiatr.?vol.27?no.3?S? Paulo?Sept.?2005
download article in pdf format
ScienTI Curriculum
How you cites this article
LETTERS TO THE PUBLISHERS
The memantina as adjuvant therapy for the negative symptoms of the schizophrenia
Memantine an adjunctive therapy will be schizophrenia negative symptoms
Mr. Editor,
The atypical antipsychotics had brought a marcante improvement in the negative symptoms of the schizophrenia. However, many patients remain refractory to the remission of these symptoms, fact that worsening very the quality of life and the psicossocial deterioration of these individuals. Recently, the memantina, an antagonist of the N-metil receivers D-aspartate (NMDA), was described as a neuroprotetora substance in the schizophrenia; a 1 story of case showed the effectiveness of this fármaco in the catatônica schizophrenia. 2 to follow,
we tell to three clinical cases on the improvement of the negative symptoms with use of memantina in patients of the feminine sex with diagnosis of schizophrenia for the Dsm-iv and atypical antipsychotic use, in ambulatorial attendance.
The symptoms had been evaluated through Brief Escala of Psychiatric Evaluation Anchored Version (Bprs it) 3 before the use of the memantina (T0) and after four weeks (T4). We are unaware of other similar stories in literature until the moment.
Patient, 56 years, in use of sulpirida 800 mg per day. He presented in T0, predominantly, affective retraction and affective embotamento, being that each one of them pontuou 6 Bprs it; 3 prop up it total at this moment were 46. It was kept sulpirida in 800 mg daily and 5 memantina initiate mg per day with the 5 increment of mg to each seven days until reaching 20 mg per day. In T4, you prop up them for affective retraction and affective embotamento had diminished for 1 and 2, respectively; it props up it total was 26.
Patient B, 31 years, using risperidona 6 mg per day. The presented predominant symptoms in T0 were conceptual disorganization, that pontuou 5, affective retraction and affective embotamento, each one of them pontuou 6; it props up it total at this moment was 44. Risperidona was kept in 6 mg daily and the memantina was initiated with 5 mg per day; mg had a weekly increment of 5 up to 20 mg per day. In T4, you prop up them for affective retraction and affective embotamento each one had diminished for 4 and the conceptual disorganization remained pontuando 5; it props up it total was 39.
Patient C, 20 years, in treatment with clozapina 700 mg per day. He presented in T0, of accented form more, not habitual thoughts, that pontuou 6, affective retraction and affective embotamento, that pontuaram 4 and 6, respectively; he props up it total at this moment was 42. The clozapina was kept in 700 mg per day and 5 memantina initiate mg per day with daily 5 the weekly increment of mg up to 20 mg. In T4, you prop up them for affective retraction and affective embotamento had diminished for 1 and 2, respectively. The conceptual disorganization remained pontuando 5; it props up it total was 26.
Hiperglutamatérgicos states have been implied in the fisiopatologia of the schizophrenia. 4 the glutamato excess cause excitement in receivers NMDA, that are a classroom of glutamatérgicos receivers, allowing a calcium flow for inside of the nervous cell for long periods. This extreme influx cause lipídica peroxidação in the neurons, being able to progress for neuronal death. The esquizofrênicos present greater lipídica peroxidação 5 of that individuals without schizophrenia. The memantina, for its antagonistic action of receivers NMDA and on the basis of the results of these three clinical stories, can be useful as adjuvant therapy in the treatment of the schizophrenia, mainly of the negative symptoms.
Clarissa Severino Gamma, Paula Antunes,
Carolina Moser, Pablo Hisses Belmonte-Of-Abreu
Service of Psychiatry, Hospital of Clinics of Porto Alegre,
Porto Alegre (RS), Brazil
References
1. Rands GS. Memantine the schizophrenia a neuroprotective treatment in. Br J Psychiatry. 2005;186:77; author reply 77-8.
2. Thomas C, Carroll BT, Maley RT, Jayanti K, Koduri the schizophrenia Memantine and catatonic. Am J Psychiatry. 2005;162(3):626.
3. Roman F, Elkis H. Tradução and adaptation of an instrument of psicopatológica evaluation of the psychoses: the brief scale of psychiatric evaluation anchored version (Bprs it). J Bras Psiquiatr. 1996;45(1):43-9.
4. Bressan RA, hypothesis Pilowsky LS. The glutamatergic of schizophrenia. Rev Bras Psiquiatr. 2003;25(3):177-83.
5. Gamma CS, Salvador M, Andreazza AC, Kapczinski F, Belmonte-of-Abreu PS. séricos superoxide Levels raised dismutase and of the products of reaction with the acid tiobarbitúrico in esquizofrênicos patients cronicamente medicated. Rev Bras Psiquiatr. 2004;26 Supl 2:92.
translate.google.com
|
