[23,24-dihydrodiscodermolide analogues with simplified lactone regions]
>>Bioorg Med Chem Lett. 2006 Jan 11; [Epub ahead of print]
A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions.
Shaw SJ, Sundermann KF, Burlingame MA, Zhang D, Petryka J, Myles DC.
Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, CA 94545, USA.
A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show antiproliferative activities similar to discodermolide.<<
Still another way of modifying discodermolides. It'll be interesting to see what they settle on. Kind of neat to watch the search from the beginning like this. AB Smith, who worked on the studies to which this post links, has his own little web site. One looks for a way to attach value and IP to a natural product, I guess. This one is from a marine sponge . . .
absmithgroup.info
Cheers, Tuck |
