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Biotech / Medical : Cell Therapeutics (CTIC)

CTIC 9.090

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Jun 26 5:00 PM EST

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From: Icebrg	1/18/2006 6:37:47 PM
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Estrogen Carcinogenesis in Breast Cancer James D. Yager, Ph.D., and Nancy E. Davidson, M.D. [From tonight's issue of NEJM. (It is rather late over here in Sweden by now). This might or might not touch upon the rationale for the Pioneer study]. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. In this article, we review recent findings related to estrogen exposure and the risk of breast cancer, the mechanisms that may be involved, and the clinical implications of these findings. The weight of evidence indicates that exposure to estrogen is an important determinant of the risk of breast cancer. The mechanisms of carcinogenesis in the breast caused by estrogen include the metabolism of estrogen to genotoxic, mutagenic metabolites and the stimulation of tissue growth. Together, these processes cause initiation, promotion, and progression of carcinogenesis. Insight into the mechanisms of the causation of cancer by estrogen will identify determinants of susceptibility content.nejm.org

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