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Biotech / Medical : Merck
MRK 100.72+1.5%Dec 18 3:59 PM EST

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From: Rampex1/28/2006 3:05:44 AM
   of 1580
 
Fred,

Three more quick search results at the bottom and an excerpt from The Merck Manual on aspirin.

Cheers.

Rampex

"Aspirin has been used for about 100 years. Aspirin is taken by mouth and provides 4 to 6 hours of moderate pain relief.

Because aspirin can irritate the stomach, it may be combined with an antacid (in a buffered product) to reduce this effect. The antacid creates an alkaline environment that helps aspirin dissolve and may reduce the time aspirin is in contact with the stomach lining. However, buffered aspirin can still irritate the stomach because aspirin also reduces the production of substances that help protect the stomach's lining (these substances are a type of prostaglandin).

Enteric-coated aspirin is designed to pass through the stomach intact and dissolve in the small intestine, thus minimizing direct irritation of the stomach. (Enteric refers to the small intestine.) However, enteric-coated aspirin may be absorbed erratically. If food and enteric-coated aspirin are ingested at about the same time, the aspirin is not absorbed as quickly because food delays the emptying of the stomach. Consequently, pain relief is delayed.

Aspirin also increases the risk of bleeding throughout the body because it reduces the clotting tendency of platelets. People who bruise easily may be especially vulnerable to this effect. Anyone who has ever had a bleeding disorder or uncontrolled high blood pressure should not take aspirin except under a doctor's supervision. People who take aspirin and anticoagulants (such as warfarin) are closely monitored to avoid life-threatening bleeding. Usually, aspirin should not be taken in the week before scheduled surgery.

Aspirin can aggravate asthma. People with nasal polyps are likely to develop wheezing if they take aspirin. A few people, who are sensitive (allergic) to aspirin, may have a severe allergic reaction (anaphylaxis), leading to a rash, itching, severe breathing problems, or shock (see Shock). Such a reaction requires immediate medical attention."


thegreenwoodcenter.com
bambergercenter.com
bmj.bmjjournals.com
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