2006 - Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice.
Almeida RC, Souza DG, Soletti RC, Lopez MG, Rodrigues AL, Gabilan NH.
Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040-900, SC, Brazil.
This study investigated the cellular signaling pathways involved in the acute antidepressant-like action of memantine in the forced swimming test (FST) in mice. The immobility time in the FST was reduced by memantine (3-10mg/kg, i.p.). The anti-immobility effect of memantine (3mg/kg, i.p.) was prevented by pretreatment with H-89 (1mug/site, i.c.v., an inhibitor of PKA), PD098059 (5mug/site, i.c.v., an inhibitor of MAPK/ERK), KN-62 (1mug/site, i.c.v., an inhibitor of CaMKII), but not with chelerythrine (1mug/site, i.c.v., an inhibitor of PKC).
Taken together, these results firstly demonstrate that the acute antidepressant-like effect of memantine seems to be dependent on the cellular signaling modulated by PKA, CaMKII and MAPK/ERK, but not by PKC.
PMID: 16289784 [PubMed - in process] |
