I was poking around in cyberspace with search word: cytokine and found a couple of things..sorry if they're not relevant here[please let me know if not]Curr Opin Pharmacol. 2006 Feb 14; [Epub ahead of print] Links
Role of HMGB1 in cardiovascular diseases.
Li W, Sama AE, Wang H.
Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA; Center for Immunology & Inflammation, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
A nuclear protein, high mobility group box 1 (HMGB1), is released passively by necrotic cells, and actively by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli. After binding to the receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4), HMGB1 activates vascular endothelial cells and macrophages/monocytes to express proinflammatory cytokines, chemokines and adhesion molecules. Pharmacological suppression of its activities or release is protective against lethal endotoxemia and sepsis, establishing HMGB1 as a critical mediator of lethal systemic inflammation. In light of the pathogenic role of inflammation in cardiovascular diseases, we propose that HMGB1, a proinflammatory cytokine derived from both injured endothelium and activated macrophages/monocytes, could contribute to the progression of atherosclerosis and other cardiovascular diseases.
PMID: 16487750 [PubMed - as supplied by publisher]
Extracellular hsp70 levels in children with septic shock*.
Pediatric Critical Care Medicine. 6(3):308-311, May 2005.
Wheeler, Derek S. MD; Fisher, Lyle E. Jr MD; Catravas, John D. PhD; Jacobs, Brian R. MD; Carcillo, Joseph A. MD; Wong, Hector R. MD
Abstract:
Objective: To determine whether hsp70 is elevated in the plasma of children with septic shock.
Design: Cohort study.
Setting: Two academic, tertiary pediatric intensive care units.
Patients: Ninety-four children admitted to the pediatric intensive care unit with septic shock and 24 control children undergoing elective surgical procedures.
Interventions: Venous or arterial blood sampling.
Measurements and Main Results: Children admitted to the pediatric intensive care unit with a diagnosis of septic shock were enrolled in the study following written informed consent. The control group consisted of healthy children undergoing elective surgical procedures. Blood samples from children in the septic shock or control groups were obtained within 24 hrs of admission to the pediatric intensive care unit or during the preoperative visit. Samples were collected, centrifuged, and stored at -70[degrees]C. The hsp70 levels were measured using a commercially available enzyme-linked immunosorbent assay. Results were analyzed by Wilcoxon's rank sum test. Extracellular hsp70 levels in children with septic shock were significantly elevated compared with control patients (51.6 ng/mL vs. 8.1 ng/mL, respectively, p = .0004).
Conclusions: Extracellular hsp70 levels are significantly elevated in children with septic shock compared with controls. Given the newly described cell signaling properties of hsp70, these data suggest that extracellular hsp70 may play a role in the host response during septic shock.
(C)2005The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies |
