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Biotech / Medical : SARS and Avian Flu
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From: scaram(o)uche2/23/2006 1:50:38 AM
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Antiviral Resistance in Influenza Viruses — Implications for Management and Pandemic Response

Frederick G. Hayden, M.D.

content.nejm.org

(snip)

The high frequency of resistance among recent isolates of influenza A (H3N2) from North America appears to be attributable to an unprecedented global spread of viruses with a specific mutation (Ser31Asn), which has occurred despite the absence of sustained selective drug pressure. This observation clearly indicates that this mutation does not reduce transmissibility. Indeed, the fact that this particular mutation has been found consistently in community isolates of H3N2 whereas other resistance mutations are uncommon, along with the fact that this mutation has not been found in high frequency in isolates of H1N1, suggests that it confers a transmission advantage, perhaps mediated by compensatory mutations in other genes, or that it has been incorporated into efficiently spreading viruses.

(snip)
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