Critical Therapeutics Announces Research on ZYFLO(R) Presented at 2006 AAAAI Annual Meeting
Monday March 6, 4:45 pm ET
LEXINGTON, Mass.--(BUSINESS WIRE)--March 6, 2006--Critical Therapeutics, Inc. (Nasdaq: CRTX - News) today announced that two scientific posters on ZYFLO® (zileuton tablets) were presented at the American Academy of Allergy, Asthma & Immunology (AAAAI) 2006 Annual Meeting in Miami Beach, Florida.
William E. Berger, M.D., of Southern California Research, Mission Viejo, California, and Robert A. Nathan, M.D., of Asthma and Allergy Associates in Colorado Springs, Colorado, were lead authors of the posters.
The data were generated from retrospective analyses of two pivotal, randomized, placebo-controlled, double-blind, parallel, multi-center studies of the safety and efficacy of zileuton in 966 asthmatics. Both posters contained data from 483 asthma patients stratified into two patient groups, those with baseline forced expiratory volume (FEV(1)), a measure of lung function, of greater than 60%- less than 80% (n=257) and those with FEV(1) of less than or equal to 60% (n=226). Lung function measurements were obtained from patients on 600 mg zileuton four times per day (the prescribed dose) compared with placebo.
Lung Function
Data in Dr. Berger's poster noted that both zileuton patient groups experienced improvement in trough FEV(1) and peak expiratory flow rate (PEFR) compared with placebo.
Rescue Medication Use
Data in Dr. Nathan's poster noted that both zileuton patient groups showed decreases in asthma symptoms compared with placebo. Both zileuton patient groups also demonstrated a reduced need for beta-agonists and corticosteroid rescue.
The AAAAI is the largest professional medical specialty organization in the United States representing allergists, asthma specialists, clinical immunologists, allied health professionals and others with a special interest in the research and treatment of allergic disease. The 2006 AAAAI Annual Meeting is being held March 3-7 in Miami Beach, Florida. Abstracts of the posters presented by Dr. Berger and Dr. Nathan are available by clicking on the "Annual Meeting Abstracts" link at aaaai.org. |
