Where to Find People w/Meningococcal infections for testing of BPI methods for medical cure(s). See article below:
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The New England Journal of Medicine -- September 19, 1996 -- Volume 335, Number 12
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Meningococcal Disease in Los Angeles County, California, and among Men in the County Jails
Jordan W. Tappero, Roshan Reporter, Jay D. Wenger, Bridget A. Ward, Michael W. Reeves, Timm S. Missbach, Brian D. Plikaytis, Laurene Mascola, Anne Schuchat
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Abstract
Background. From January through March 1993, there were 54 cases of meningococcal disease in Los Angeles County, California, of which 9 occurred among men incarcerated in the county's jail system, which was 40 percent above capacity at the time. Several of the 45 patients from the community had had contact with men recently released from a county jail.
Methods. We interviewed patients from the community (n = 42) and neighborhood controls matched with the patients for age, race, and ethnic group (n = 84) about potential exposures. We collected and cultured pharyngeal swabs for Neisseria meningitidis from men entering the central jail (n = 162), men leaving the central jail (n = 379), members of the jail staff (n = 121), and patients at a community health center (n = 214). Meningococcal isolates were identified by serogrouping and multilocus enzyme electrophoresis.
Results. The presence of community-acquired meningococcal disease was strongly associated with exposure to a person who had been in or worked at one of the county jails (multivariate matched odds ratio, 18.5; 95 percent confidence interval, 3.8 to 90.8; P<0.001). Pharyngeal carriage of meningococcus was significantly more frequent among men released from jail (19 percent) or entering jail (17 percent) than among workers at the jails (3 percent) or community residents seen at the clinic (1 percent). Among men entering jail, those who had previously been incarcerated were more often carriers than those who had not (21 percent vs. 7 percent, P = 0.03). Of the isolates from nine community residents with serogroup C meningococcal disease, eight were the same strain as that isolated from the eight inmates with serogroup C disease.
Conclusions. In this outbreak of meningococcal disease in Los Angeles County, nearly half of community residents with the disease had contact with persons who had been in a county jail. The high rates of carriage among recidivists and released inmates suggest that the men became meningococcal carriers while in jail. (N Engl J Med 1996;335:833-40.)
Source Information
From the Childhood and Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases (J.W.T., J.D.W., M.W.R., T.S.M., A.S.), and the Biostatistics and Information Branch (B.D.P.), National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta; and Acute Communicable Disease Control, Public Health Programs and Services, Los Angeles County Department of Health Services, Los Angeles (R.R., B.A.W., L.M.). Address reprint requests to Dr. Schuchat at the Childhood and Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Mailstop C-09, Centers for Disease Control and Prevention, 1600 Clifton Rd., N.E., Atlanta, GA 30333. |
