Ablynx Reveals Power of Nanoclone - a High Throughput Method for Isolating Highly Potent Antibody-derived Therapeutic Proteins (nanobodies)
medadnews.com
GHENT, Belgium and London, UK, 14th March 2006 - Speaking at the Drug Discovery Technology Europe 2006 Conference (London), Dr. Hennie Hoogenboom, CSO of Ablynx, for the first time presented data that reveal how Ablynx has been rapidly generating high affinity, picomolar potency Nanobodies™ using Ablynx’s proprietary Nanoclone™ discovery engine. Ablynx has been applying Nanoclone™ as part of its drug discovery efforts to generate Nanobodies™, a novel class of antibody-based therapeutics.
Using Nanoclone™, Ablynx is able to rapidly identify B-cells that produce heavy-chain antibodies that are not only specific for a particular target antigen, but also bind to the antigen with a very high affinity. Nanoclone™ is fast, easy to use and gives Ablynx a direct route to the identification of highly potent Nanobody™ leads. |
