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Biotech / Medical : Biotech Valuation

CRSP 49.89

-6.4%

3:22 PM EST

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To: Ian@SI who wrote (19431)	3/23/2006 1:33:17 PM
From: dr.praveen	Read Replies (2) of 52153

Aptamers/Hi Ian, Noxxon licensed Aptamer tech from Archemix which is the leader and holds most of the patents. See the news Archemix and Nuvelo Close Phase I Trial for Thrombin Inhibitor, ARC183 - With "Proof of Concept" Achieved, Companies Actively Pursuing an Optimized Second Generation Molecule at the link below. archemix.com Another one is from Antisoma AS1411 which acquired Aptamera.And you know Macugen from eyetech is another example. AS1411 (formerly AGRO100) is a novel aptamer drug that was added to Antisoma's pipeline through the acquisition of the US cancer company Aptamera in February 2005. It binds to the protein nucleolin, which is normally found inside cells, but which presents on the cell surface in a wide range of cancers. Such binding can induce the death of cancer cells that make nucleolin. AS1411 has been tested in a phase I study of 17 patients and has shown encouraging signs of anti-cancer activity. antisoma.com This link will tell you more about the technology Message 21551234 Regards, Praveen

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