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Biotech / Medical : Cortex (Cor) [formerly CORX]
COR 329.85-8.8%3:59 PM EST

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From: sim13/27/2006 7:47:48 AM
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27-Mar-2006

Termination of a Material Definitive Agreement

Item 1.02. Termination of Material Definitive Agreement.

On March 21, 2006, Cortex Pharmaceuticals, Inc. (the "Company") delivered notice to the Institut de Recherches Internationales Servier and Les Laboratoires Servier (collectively, "Servier") that, pursuant to the terms of Section 3.1 of the Research Collaboration Agreement between the Company and Servier dated October 13, 2000, as amended (the "Agreement"), the Company has elected to terminate the research phase of the collaboration (the "Research Phase") and the Agreement effective December 7, 2006. The Company is currently having further discussions with Servier regarding the possibility of terminating the Research Phase and Agreement at an earlier date.

Under the terms of the Agreement, the Company and Servier collaborated to identify, evaluate and develop AMPAKINE compounds for use in the treatment of memory impairment associated with aging and neurodegenerative diseases. Under the Agreement, the Company currently receives approximately $2,298,000 per year (subject to the Company providing agreed-upon levels of research) and Servier is obligated to continue this level of support until early December 2006, or an earlier termination date, if agreed upon by Servier.

The Research Phase and the Agreement shall continue in full force until the termination becomes effective (in any event, no later than December 7, 2006) and the Company will not incur any early termination penalties as result of this termination. The Company shall make every effort to wind down the Agreement in a constructive manner, reflecting the good relationship that the Company has had with Servier. The Licensing Agreement, dated October 13, 2000, as amended to date, will continue in accordance with its terms.
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