Sonki, Re: ZONAGEN, Vivus Competition:
Here is one of the first posts I wrote on Phentolamine/"Vasomax"/made by Zonnagen, in May 97, when Vivus was 30!!( 15 !!! ) pre-split;nothing has changed since:
I am amazed at the amount of
dis/misinformation that exists on Muse! A doctor turns his back
for a couple of minutes and all the kooks come out!!!!! Amazing!!
It will take a while for me to clear it but I hope to persuade you
that Muse is one of the greatest investments ever and at +/- $30a
share it is a steal considering that it has a PE of 15 with a yearly
growth athat is starting at a 100% and is accelerating towards>200%!!
It has a monopoly with zero competition at least for the next 3-4
years!!!Target price is $400 in 3 years?!
Where do we start? The competition: Zonnagen 1st. I was deeply disap
pointed by L.Benko's article in IBD on Zonnagen/Vasomax .It,s main
ingredient is phentolamine and she says it has been approved already
for treatment of hypertension. Yeah:30 yers ago! Call your Doc or
Pharmacist or read the PDR!You can buy Phentolamine right now at your
Drug store for 3-5 bucks probably for a 100 tabs!!! ( it 's been out
of patent for 20 years ) They may have to special order it though
because I don't think anybody carries it since THIS IS A DANGEROUS
KILLER DRUG. Currently it is only used in Intensive Care Units to
artificially lower the blood pressure to <100 millim.of merc. in peo
ple with a failing heart ( with congestive heart failure ) in as much
as by lowering the blood pressure and arterial resistance makes it
easierfor the failing weak heart to pump blood out. Of course this is
dangerous (lowering the blood pressure in somebody with an already low Blood Pressure ) and so we simultaneously one must monitor TWO blood pressures ,the arterial AND the venous, through two
indwelling catheters, one in the artery the other one in the vein,and thus monitor every single heart beat/blood pressure. Of course you can't get out of bed while this is happening not only because these type of patients are usually moribund to bagin with but if they didget up they would have orthostatic hypotesion ( "low BP on standing")and croak right there.T he last time I used it was 20 years ago while I was in training as an intern and only because may mentor told me to.Both patients died and that was the end of it for me. I haven't ( or anybody I know) used it since, ecxept once in a rare case of Pheochromacytoma tumor that I had to remove.
.Currently the only there are only two indications for it:
One is in the temporary intraoperative control
of the sky high hypertension that occurs when we remove a RARE tumor
near the kidney called a Pheochromocytoma and the second indication
is to counteract (through its potent vasodilatory properties ) the
severe vasoconstriction that occurs when the vasocostrictive drug
Dopamine accidentally extravasates during IntraVenous infusion and causes skin necrosis and sloughig-off with gangrene( skin turns black and then becomes like rotten meat; ( get your lawyer readyalso at the same time in this case, unless you can get phentolamine in immmediately and counteract the vasoconstriction with vasodilatation;that fortunately usually reverses it immediately ) .
PDR (physician's desk reference ) clearly states that oral Phentolamine causes hypotension and as a result of that ,aggravation of angina pectoris, acute myocardial infarction,cerebral vasvular necrosis/infarction/stroke/lermanent paralysis of half your body and/ or death from shock.
Zonnagen is simply on a PR campaign. I wouldn't be surprised if the insiders sell giant amount of stock.The FDA will NEVER IMHO approve this drug for ED therapy.I would short the stock the next time there
is another company PR campaign that spikes the price tp +/- 35.
TA
PS : I've intended for a long time to post Vasomax / phentolamine as found in the PDR on this threasd. I will try and do it.
TA |
