ReNeuron Group plc 04 April 2006
ReNeuron announces initial pre-clinical data with its ReN003 retinal stem cell programme and signs collaboration agreement with Schepens Eye Research Institute
Guildford, UK, 4 April 2006: ReNeuron Group plc (LSE: RENE.L) today announces initial survival efficacy data with its ReN003 stem cell therapy programme for diseases of the retina. The joint research, led by Professors John Greenwood and Stephen Moss at the UCL Institute of Ophthalmology in London, showed expansion of human retinal progenitor cells with markers of photoreceptors over multiple population doublings. These progenitors showed an ability to engraft and protect the photoreceptor layer of the retina from degeneration in a retinal dystrophic model.
The research was funded by a Medical Research Council stem cells strategic research grant, and will be presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Fort Lauderdale, Florida on 30 April to May 4, 2006.
In order to further its ReN003 retinal stem cell programme, ReNeuron today also announces that it has entered into a collaborative research agreement with the Schepens Eye Research Institute at Harvard Medical School, Boston, US. The research programme under this collaboration will take place in the laboratories of Dr Michael Young, and aims to establish the key conditions for growing retinal stem cell lines that can be developed into a scalable, efficacious and safe therapy that utilises ReNeuron's proprietary c-mycERTAM expansion technology. The objective is to develop these stem cell lines to treat major blindness- causing diseases such as age-related macular degeneration, retinitis pigmentosa and diabetic retinopathy, which together represent a major unmet medical need.
Dr John Sinden, Chief Scientific Officer of ReNeuron, said:
'I am delighted that ReNeuron is working so closely with both the UCL Institute of Ophthalmology and the Schepens, two of the world's major research and clinical centres in the field of retinal diseases. Our new collaboration with Schepens will combine their important patented technology and know-how with ReNeuron's versatile stem cell platform, with the aim of generating novel stem cell therapies for these major retinal diseases. Future collaborations with both institutions offer the potential to take these therapies through to the clinic in the most efficient way possible.'... |