Corixa [CRXA] - cancer vaccines Message Board

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Biotech / Medical : Corixa [CRXA] - cancer vaccines

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To: nigel bates who wrote (221)	7/12/2006 2:25:18 PM
From: scaram(o)uche	of 222

Results in human subjects showed that antibody levels induced by the HPV vaccine formulated with the AS04 adjuvant system were 1.5 to 2.1 times higher for HPV 16 and HPV 18 respectively than those induced following vaccination with the aluminium formulation at 4 years. These data also demonstrate the potential ability of the AS04 adjuvanted vaccine to increase immune memory. Following vaccination with the AS04 formulation of GSK's cervical cancer candidate vaccine, observed numbers of memory B cells were 2 to 3.6 times higher for HPV 18 and HPV 16 respectively than those observed with the aluminium formulation. Immune memory B cells have been shown to be essential to the persistence of antibody levels following vaccination. Immunologists -- serologists -- who have worked with adjuvants like Freund's? We snicker in the general direction of such modest numbers.

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