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Biotech / Medical : Biotech Valuation
CRSP 55.26+1.2%3:59 PM EST

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To: NeuroInvestment who wrote (20666)7/28/2006 6:24:45 PM
From: Miljenko Zuanic  Read Replies (1) of 52153
 
Harry,

NXY-059 MAY be a first-generation version of that?

Anti-oxidative neuro-protection?

The dose that AZN is using in SAINT is too high to indicate true protective mechanism (anti-oxidative???) that may lead to post-stroke recovery and benefit.

I didn’t found any reliable data to show what percentage of the circulating drug does reach brain area (it is di-sodium salt),
ncbi.nlm.nih.gov

so, are there possibilities for other mechanisms or de-sulfonyation to PBN is one option …?

Yes, first PIII data indicate marginal benefit, but how will FDA react if there is no benefit in NIHSS analysis is main issue here, regardless of the AZN approach to problem? I didn’t follow field for years, so would like opinion from someone more familiar with current medicine.

Miljenko
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