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Biotech / Medical : NTEG- Bloodless Glucose Monitor

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To: DryHeat who wrote (28)9/24/1997 1:01:00 PM
From: Stratajema   of 176
 
According to Mosby Publications, the University of Minnesota study of ISF (sponsored by Integ) will be published in the October '97 issue of the Journal of Laboratory and Clinical Medicine. This journal is not on-line but can be found in many university libraries. The U of M study was conducted on subjects fasting with their glucose values in a state of rapid change. This ISF study is the most important since the results of the study appear to dispel the delay factor of glucose transport from the blood to the dermal layers of skin.

Norbert, I would appreciate it if you could post the telephone number or email address found on the detailed Mayo study where reprints can be obtained. How many pages are in the study?

I agree that the time lag and handling issues of the ISF samples used in the studies may have created some variability in the correlation statistics. However, I think we can assume a .95 correlation will be the scientific reference point.

I suspect you obtained the .99 correlation coefficient number from Integ's 10K. (The wording surrounding this correlation is not clear in the 10K.) I initially concluded that the 345 samples used in that test were non-physiologic samples that contained known glucose values for the purpose of testing their meter components. This is typically the starting point for testing the accuracy of a device since physiologic samples will create interferences in measurement that must be addressed. Apparently, these physiologic interferences and the consistency of measurement are the issues Integ is now addressing.

Here is a little tid bit of info to think about. The correlation of glucose in ISF to glucose in capillary blood or venous blood is not as important as the correlation of ISF glucose to brain ISF glucose. (The brain is the most important organ in the body.) As you can imagine, such a study can not be realistically conducted.
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