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Biotech / Medical : Infinity Pharmaceuticals
INFI 0.0160-4.8%Sep 29 5:00 PM EST

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To: Mike McFarland who wrote (53)8/1/2006 5:46:20 PM
From: Mike McFarland  Read Replies (1) of 210
 
There may be an inherent limit to the efficacy of direct
Hsp90 inhibition, resulting from induction of the
antiapoptotic chaperone Hsp70. Other mechanisms, such as
HDAC inhibition, can also affect the Hsp90 chaperone, and a
combination of direct Hsp90 inhibitors and HDAC
inhibitors, or Hsp90 inhibitors in combination with standard
chemotherapeutics and newer targeted agents, may provide
the most productive way forward.


Targeting Hsp90 for the treatment of cancer
(Vernalis, Novartis authors)

Current Opinion in Drug Discovery & Development 2006 9(4):483-495
thomson-pharma.com

Infinity, Kosan, Conforma molecules mentioned, one to print
and read a few times--I still have not found any Chiosis
papers for free.

Today was the record date for voting on the merger.
There seems to be little interest in trading shares around/
either an "I'll play these cards" or the vote is already
figured out anyway.

google.com
That paper is the third hit using google.

Much of these papers goes over my head anyway...but
I think it likely we are not going to see any surprise
move upward to the valuation when INFI comes out.
The only play is going to be to wait for them to
build some value over time.
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