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Biotech / Medical : Northwest Biotherapeutics Inc.

NWBO 0.285

-2.2%

Feb 3 3:59 PM EST

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To: John McCarthy who wrote (47)	8/22/2006 5:11:40 AM
From: zeta1961	of 760

Detailed paper on NWBT's P1 glioblastoma vaccine..very interesting for those more inclined toward immunotherapeutic route.. clincancerres.aacrjournals.org Quite importantly, to set up P2 trial methodology, although they enrolled patients 'as they came,' those needing steroids like dexamethasone were excluded..this criterium naturally selects for patients with tumors in less harmful parts of the brain and for those whose tumor was excisable even if not completely..they admitted these limitations in this piece..acknowledging, they compared against historicals of patients with the best prognostic factors(age, tumor size and location and neuro deficits) and still the TTP and OS were better than expected.. I wish Miljenko would come over here and break my and their analysis apart.. Elisabeth

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